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Article

Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi-Omics Framework.

CNS neuroscience & therapeutics - 1 Sept 2026

Li Zesheng, Wang Yihe, Shi Jianwei, Luo Yumin, Shan Yongzhi, Zhao Guoguang

Abstract excerpt

BACKGROUND: Focal cortical dysplasia Type II (FCD II) is a major cause of drug-resistant epilepsy in children. Somatic mosaic variants affecting the PI3K-AKT-mTOR pathway are implicated in a substantial proportion of cases. The links between genotype, cellular pathology, epileptogenic networks, and clinical outcome remain incompletely defined. METHODS: This review synthesizes evidence on somatic mTOR-pathway...

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Topics

Humans
Mutation
Focal Cortical Dysplasia
Animals
Malformations of Cortical Development, Group I
Multiomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

TOR Serine-Threonine Kinases

Signal Transduction

Source

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Identifiers

PMID: 42773933
DOI: 10.1002/cns.71170
PMCID: PMC13598546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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