Article

Semaphorin 4D induces an imbalance of Th17/Treg cells by activating the aryl hydrocarbon receptor in ankylosing spodylitis

2020-03-26

Abstract excerpt

<h4>Background: </h4> Semaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity. We undertook this study to investigate the mechanism by which Sema4D affects the pathogenic progress of ankylosing spondylitis (AS). <h4>Methods:</h4> Soluble...

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Literature Corpus work: 9749635b-5608-5362-9828-c4a86eb3798f
DOI: 10.21203/rs.3.rs-18464/v1

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