Article

Obesity and adiposity have opposing genetic impacts on human blood traits

2021-11-07

Abstract excerpt

Obesity, hyperlipidemia, and truncal adiposity concordantly elevate cardiovascular disease risks, but have unknown genetic effects on blood trait variation. Using Mendelian randomization, we define unexpectedly opposing roles for generalized obesity and truncal adiposity on blood traits. Elevated genetically determined body mass index (BMI) and lipid levels decreased hemoglobin and hematocrit levels, explaining co...

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Literature Corpus work: e876f031-a12a-543e-83db-db24e59ae0e7
DOI: 10.1101/2021.11.05.467482

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