Article

Composite trait Mendelian Randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

2020-09-05

Abstract excerpt

Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the impact of specific aspects of body morphology remains poorly understood. We combined the GWAS summary statistics of fourteen anthropometric traits from UK Biobank through principal component analysis to reveal four major independent axes summarizing 99% of genetically driven variation in body shape and size: overall body size,...

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Literature Corpus work: 8d390f47-33d4-5817-ae20-2fe3fa72433b
DOI: 10.1101/2020.09.03.20187567

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