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Article

Body mass index and adipose distribution have opposing genetic impacts on human blood traits.

eLife - 15 Feb 2022

Thom Christopher S, Wilken Madison B, Chou Stella T, Voight Benjamin F

Abstract excerpt

Body mass index (BMI), hyperlipidemia, and truncal adipose distribution concordantly elevate cardiovascular disease risks, but have unknown genetic effects on blood trait variation. Using Mendelian randomization, we define unexpectedly opposing roles for increased BMI and truncal adipose distribution on blood traits. Elevated genetically determined BMI and lipid levels decreased hemoglobin and hematocrit levels,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35166671
DOI: 10.7554/eLife.75317
PMCID: PMC8884725

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