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Mesenchymal Neuroblastoma Cells Lack Critical Transporters for mIBG Uptake and May Evade Detection and Therapy

2025-10-03

Abstract excerpt

<title>Abstract</title> <p> Background Neuroblastoma exhibits phenotypic heterogeneity with two main transcriptional states: adrenergic (ADRN) and mesenchymal (MES). MES neuroblastoma cells are linked to increased motility and chemoresistance, but their capacity to accumulate meta-iodobenzylguanidine (mIBG)—a cornerstone in neuroblastoma imaging and therapy—remains unclear. We hypothesized that MES cells fail to...

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Literature Corpus work
e84d1bb8-1879-5b48-9b37-3304f4fc5f2b
DOI
10.21203/rs.3.rs-7480401/v1
Open publication

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