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Article

Nothing but NET: A review of norepinephrine transporter expression and efficacy of<sup>131</sup>I‐mIBG therapy

30 Aug 2014

Abstract excerpt

Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on imaging, yet the therapeutic response to (131) I-mIBG is only 30% in clinical trials, and off-target effects cause...

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PMID: 25175627
DOI: 10.1002/pbc.25200

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