Article

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

2021-05-24

Abstract excerpt

<h4>Summary</h4> Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a library of human interferon-stimulated genes (ISGs), we identified TRIM25 as a potent inhibitor of EBOV transcription-and-replication-competent virus-like particle (trVLP) propagation. TRIM25 overexpression inhibited the accumulation of viral genomic and messenger RNAs independently of the RNA sensor RIG-I or sec...

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Identifiers and source

Literature Corpus work: e82ff9c2-f46f-5c36-bd1d-07ff8557ae1f
DOI: 10.1101/2021.05.23.445113

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