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TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

9 May 2022

Abstract excerpt

Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a library of human interferon-stimulated genes (ISGs), we identified TRIM25 as a potent inhibitor of EBOV transcription-and-replication-competent virus-like particle (trVLP) propagation. TRIM25 overexpression inhibited the accumulation of viral genomic and messenger RNAs independently of the RNA sensor RIG-I or secondary...

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PMID: 35533151
DOI: 10.1371/journal.ppat.1010530

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