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N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by competitively sponging miR-139-5p and activating the Wnt signaling pathway

2022-01-17

Abstract excerpt

<h4>Background: </h4> Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. Hence, there is an urgent need to enhance the sensitivity of PC to gemcitabine (GEM). Methods A patient-derived xenograft model was used for screening the hub lncRNAs affecting GEM chem...

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Literature Corpus work
9d9cd3a5-32c4-515f-8da2-65018018556e
DOI
10.21203/rs.3.rs-1242747/v1
Open publication

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N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by competitively sponging miR-139-5p and activating the Wnt signaling pathwayDOI 10.21203/rs.3.rs-1242747/v1
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