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Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer

11 Mar 2025

Abstract excerpt

We determined triple-negative breast cancer (TNBC) subtypes, genetic ancestry, and immune features in a cohort of self-reported Black females with TNBC diagnosed at or below age 50. Among 104 tumors, 34.6% were basal-like 1 (BL1), 17.3% basal-like 2 (BL2), 9.6% luminal androgen receptor (LAR), 26.9% mesenchymal (M), and 11.5% unsubtyped (UNS). Subtypes resembled those seen in Europeans or East Asians, with less...

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PMID: 40069179
DOI: 10.1038/s41523-025-00731-0

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