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Article

African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women.

Genome medicine - 7 May 2026

Jia Guochong, Liu Lili, Ping Jie, Fiorica Peter N, Guo Xingyi, Tao Ran, Li Bingshan, Gu Jian, John Esther M, Olopade Olufunmilayo I, Press Michael F, Brewster Abenaa M, Olshan Andrew F, Zirpoli Gary, Butler Ebonee N, Huang Maosheng, Huo Dezheng, Palmer Julie R, Haiman Christopher A, Ambrosone Christine B, Troester Melissa A, Long Jirong, Yao Song, Zheng Wei

Abstract excerpt

BACKGROUND: Compared to European American women, African American women are more likely to be diagnosed with triple-negative breast cancer (TNBC). This difference may be partially due to genetic factors. This study aims to investigate associations of African ancestry and risk variants with TNBC among African American women. METHODS: We used data from 2,335 TNBC cases, 8,159 estrogen receptor (ER)-positive cases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42098873
DOI: 10.1186/s13073-026-01665-3
PMCID: PMC13321428

Genes

MDM4
MRPL36
TCF7L2
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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