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Membrane Tethering of Honeybee Antimicrobial Peptides in <i>Drosophila</i> Enhances Pathogen Defense at the Cost of Stress-Induced Host Vulnerability

2025-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Antimicrobial peptides (AMPs) represent a promising alternative to conventional antibiotics in combating multidrug-resistant pathogens, yet their clinical translation is hindered by proteolytic instability, cytotoxicity, and poor bioavailability. Here, we demonstrate that glycosylphosphatidylinositol (GPI)-mediated membrane tethering of honeybee defensin1 (Def1) in Drosophila melanogaster enhan...

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Literature Corpus work
e7b998b8-3718-5a5d-bb76-a28d4713d100
DOI
10.1101/2025.07.17.665347
Open publication

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Membrane Tethering of Honeybee Antimicrobial Peptides in <i>Drosophila</i> Enhances Pathogen Defense at the Cost of Stress-Induced Host VulnerabilityDOI 10.1101/2025.07.17.665347
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