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Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity

2021-12-13

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 nucleocapsid protein (N) induces strong antibody and T cell responses. Although considered to be localized in the cytosol, we readily detect N on the surface of live cells. N released by SARS-CoV-2 infected cells or N-expressing transfected cells binds to neighboring cells by electrostatic high-affinity binding to heparan sulfate and heparin, but not other sulfated glycosaminoglycans....

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Literature Corpus work
e63d32a7-2a8d-510e-8fa7-43b1d43d77d2
DOI
10.1101/2021.12.10.472169
Open publication

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Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive ImmunityDOI 10.1101/2021.12.10.472169
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