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Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition

2024-03-18

Abstract excerpt

SARS-CoV-2 infection triggers strong antibody response toward Nucleocapsid-Protein (NP), suggesting extracellular presence beyond its intra-virion RNA binding. Interestingly, NP was found to decorate infected and proximal uninfected cell-surfaces. Here, we propose a new mechanism through which extracellular NP on uninfected cells contributes to COVID-19 pathogenicity. We show that NP binds to cell-surface sulfated...

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Identifiers and source

Literature Corpus work
d969225a-934c-58ec-961e-2d4b937555ad
DOI
10.1101/2024.03.17.585388
Open publication

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Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement depositionDOI 10.1101/2024.03.17.585388
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