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Differences in the co-distribution of the Cannabinoid Receptor-1, FAAH, and MAGL in the human and mouse brain could be limiting clinical translation of endocannabinoid outcomes in mouse models of Alzheimer disease

2025-12-12

Abstract excerpt

Endocannabinoid system (ECS) outcomes in mouse models of Alzheimer disease (AD) do not always align with the clinical disease course. We compared the distribution of the Cannabinoid Receptor-1 (CB1R) and the enzymes, FAAH and MAGL, in autopsy AD brain samples as well as in the ‘J20’ (hAPP Swe/Ind ) mouse model of AD. Both sources revealed several anti-CB1R immunoreactive species, e.g . one at 47-kDa (correspondi...

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Literature Corpus work
e7af792d-6ae9-54c4-9a41-fbfc9955dc01
DOI
10.64898/2025.12.10.693257
Open publication

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Differences in the co-distribution of the Cannabinoid Receptor-1, FAAH, and MAGL in the human and mouse brain could be limiting clinical translation of endocannabinoid outcomes in mouse models of Alzheimer diseaseDOI 10.64898/2025.12.10.693257
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