Article

Silencing of KNTC1 inhibits hepatocellular carcinoma cells progression via suppressing PI3K/Akt pathway

2020-10-28

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Kinetochore associated 1 (KNTC1) encodes a kinetochore component in Rod-Zwilch-ZW10 (RZZ) complex which is essential for the segregation of sister chromatids during mitosis and participates in the spindle checkpoint. Recent research demonstrated that kinetochore proteins may be potential biomarkers and may contribute to the development of human malignancies....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0fa4d11-543e-5759-96b0-0c0956a440bb
DOI: 10.21203/rs.3.rs-32661/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Silencing of KNTC1 inhibits hepatocellular carcinoma cells progression via suppressing PI3K/Akt pathwayDOI 10.21203/rs.3.rs-32661/v3Read

shRNA‑mediated knockdown of KNTC1 suppresses cell viability and induces apoptosis in esophageal squamous cell carcinomaSemantic proximity Read

KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancerSemantic proximity Read

NamiRNA-mediated high expression of KNSTRN correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinomaSemantic proximity Read

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.Semantic proximity Read

ZW10 interacting kinetochore protein may serve as a prognostic biomarker for human breast cancer: An integrated bioinformatics analysisSemantic proximity Read

ESCO2 promotes the proliferation of hepatocellular carcinoma through PI3K/AKT/ mTOR signaling pathwaySemantic proximity Read

NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent mannerSemantic proximity Read

CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζSemantic proximity Read

Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and MigrationSemantic proximity Read

SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathwaySemantic proximity Read

TOX3 drives hepatocellular carcinoma progression by suppressing the p53-p21-Rb pathwaySemantic proximity Read

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationSemantic proximity Read