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A new T-antigen negative HEK293 cell line with improved AAV productivity

2023-01-20

Abstract excerpt

Viral vectors for gene therapy, such as recombinant Adeno-Associated Viruses (rAAV), are produced in Human Embryonic Kidney (HEK) 293 cells. However, the presence of the SV40 T-antigen-encoding CDS SV40GP6 and SV40GP7 in the HEK293T genome raises safety issues when these cells are used in manufacturing for clinical purposes. We developed a new T-antigen-negative HEK cell line from ExcellGene’s proprietary HEKExp...

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Literature Corpus work
e78a4957-86ed-577d-a765-910e342d3711
DOI
10.22541/au.167424853.33255289/v1
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A new T-antigen negative HEK293 cell line with improved AAV productivityDOI 10.22541/au.167424853.33255289/v1
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