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Engineered CHO cells as a novel AAV production platform for gene therapy delivery

6 Nov 2023

Abstract excerpt

Abstract The Herpes simplex virus (HSV)-based platform for production of recombinant adeno-associated viral vectors (rAAVs) yields higher titers and increased percentage of full capsids when compared to the triple transient transfection (TTT) method. However, this platform currently faces two major challenges. The first challenge is the reliance on commercial media, sometimes supplemented with serum, leading to...

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Share to Herpesvirus Infections and Treatments
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PMID: 37932360
DOI: 10.1038/s41598-023-46298-3

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