Article

Whole mouse body histology using standard IgG antibodies

2023-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Most diseases involve multiple interconnected physiological systems, but histological evaluation of their pathology is currently limited to small tissue samples. Here, we present wildDISCO, a technology that uses cholesterol extraction to enable deep tissue penetration of standard 150 kDa IgG antibodies in chemically fixed whole mice. Combining wildDISCO with whole mouse clearing, we generate wh...

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Literature Corpus work: e76c5b25-bc9e-586b-b847-f0b12ad71bc9
DOI: 10.1101/2023.02.17.528921

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