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<i>N</i> <sup>6</sup> -methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cells

2020-11-04

Abstract excerpt

N 6 -methyladenosine (m 6 A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions. RNA m 6 A modification is regulated by two groups of cellular proteins, writers and erasers that add or remove m 6 A, respectively. HIV-1 RNA contains m 6 A modifications that modulate viral infection and gene expression in cells. However, it remains unclear whether m 6 A modifi...

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Literature Corpus work
e760d3f6-5baf-5911-b08a-eb01b6dfa7cf
DOI
10.1101/2020.11.04.368712
Open publication

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