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HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication

7 Jan 2019

Abstract excerpt

N 6 -methyladenosine (m 6 A) modification of HIV-1 RNA regulates viral replication and protein expression. The m 6 A modification is regulated by two groups of cellular proteins named writers and erasers that add or remove m 6 A, respectively. HIV-1 infection of CD4 + T-cells increases m 6 A levels of cellular mRNA, but the underlying mechanism is unknown. Here, we show that HIV-1 infection of CD4 + primary...

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PMID: 30617182
DOI: 10.1074/jbc.ra118.005608

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