Article

Establishment of Human Pluripotent Stem Cell-derived Cortical Neurosphere Model to Study Pathomechanisms and Drug Sensitivity in Kleefstra Syndrome

2024-04-25

Abstract excerpt

<title>Abstract</title> In the present study, we aimed to establish and characterize a mature cortical spheroid model system for Kleefstra syndrome (KS) using patient-derived iPSC. We identified key differences in the growth behavior of KS spheroids determined by reduced proliferation marked by low Ki67 and high CDKN1A expression. Conversely, in the spheroid-based neurite outgrowth assay KS outperformed the co...

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Literature Corpus work: e757ff23-ab3f-5cba-8537-5de983a11c0a
DOI: 10.21203/rs.3.rs-4212952/v1

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