Article

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

2023-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is the most frequent form of paediatric soft-tissue sarcoma and remains a medical challenge, holding in failure current therapeutic strategies. RMS shares histological features with cells of the muscle lineage and this cancer is thought to arise from malignant transformation of myogenic precursors. It has been proposed that RMS and myogenesis could represent the “Jekyll an...

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Literature Corpus work: e73115ee-c55a-5bbd-ade0-ca2d4c4fcad4
DOI: 10.1101/2023.03.07.531559

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