Article

TIGIT-Fc Promote Immune Tolerance at the Feto-maternal Interface

2019-10-28

Abstract excerpt

The perfect synchronization of maternal immune-endocrine mechanisms and those of the foetus is necessary for a successful pregnancy. In this report, decidual immune cells at the maternal-foetal interface were detected that expressed TIGIT (T cell immunoreceptor with Ig and ITIM domains), which is a co-inhibitory receptor that triggers immunological tolerance. We generated recombinant TIGIT-Fc fusion proteins by li...

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Literature Corpus work: 7203c2cb-a1f2-58df-bce8-adba101872c4
DOI: 10.1101/819243

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