Article

Identification of picornavirus proteins that inhibit <i>de novo</i> nucleotide synthesis during infection

2025-03-11

Abstract excerpt

The picornavirus family includes well-known pathogens for humans and animals, such as enteroviruses (e.g. poliovirus, coxsackievirus, rhinovirus) and cardioviruses (e.g. encephalomyocarditis virus [EMCV] and Saffold virus). Picornaviruses modulate cellular metabolism likely to generate sufficient building blocks for virus replication. Previously, we showed that coxsackievirus B3 (CVB3) and EMCV remodel nucleotide...

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Literature Corpus work: e6f7779d-059d-54c1-ad39-9aed7240e36e
DOI: 10.1101/2025.03.11.642588

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