Article

Autoencoder-transformed transcriptome improves genotype-phenotype association studies

2023-07-25

Abstract excerpt

Transcriptome-wide association study (TWAS) is an emerging model leveraging gene expressions to direct genotype-phenotype association mapping. A key component in TWAS is the prediction of gene expressions; and many statistical approaches have been developed along this line. However, a problem is that many genes have low expression heritability, limiting the performance of any predictive model. In this work, hypoth...

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Literature Corpus work: e6b2a129-871d-5697-886e-f897a722d999
DOI: 10.1101/2023.07.23.550223

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