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Dual pathway regulation of castration response and ferroptosis in the prostate epithelium

2025-08-09

Abstract excerpt

Understanding how sex hormones maintain tissue integrity—and how their disruption can promote cancer—is a central question in biology. In the prostate, androgen signaling is crucial for development, homeostasis, and cancer, yet the molecular mechanisms underlying tissue regression after androgen-deprivation have remained unknown. Here we show that castration induces epithelial regression via ferroptosis in the nor...

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Identifiers and source

Literature Corpus work
e6b143e6-e00e-5429-8173-ef821fdfba02
DOI
10.1101/2025.08.06.668974
Open publication

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Dual pathway regulation of castration response and ferroptosis in the prostate epitheliumDOI 10.1101/2025.08.06.668974
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