Article
Cross modulation between the androgen receptor axis and protocadherin-PC in mediating neuroendocrine transdifferentiation and therapeutic resistance of prostate cancer.
Neoplasia (New York, N.Y.) - 1 Jul 2013
Terry Stéphane, Maillé Pascale, Baaddi Habiba, Kheuang Laurence, Soyeux Pascale, Nicolaiew Nathalie, Ceraline Jocelyn, Firlej Virginie, Beltran Himisha, Allory Yves, de la Taille Alexandre, Vacherot Francis
Abstract excerpt
Castration-resistant prostate cancers (CRPCs) that relapse after androgen deprivation therapies (ADTs) are responsible for the majority of mortalities from prostate cancer (PCa). While mechanisms enabling recurrent activity of androgen receptor (AR) are certainly involved in the development of CRPC, there may be factors that contribute to the process including acquired neuroendocrine (NE) cell-like behaviors...
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