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Article

The regulation of fatty acid mobilization is extravagant rather than frugal: a perspective indicating a limitation of the thrifty genotype hypothesis.

The American journal of clinical nutrition - 1 Oct 2025

Henderson Gregory C

Abstract excerpt

It has been previously proposed that humans are prone to type 2 diabetes because of thrifty genes. It was suggested that the evolution of humans following their split from other primate lineages was uniquely afflicted with cycles of feast and famine, leading to a strong drive to acquire and sequester energy to prepare for future bouts of negative energy balance. In this previous theory, the thrifty genotype...

Topics

Humans
Diabetes Mellitus, Type 2
Obesity
Genotype
Fatty Acids, Nonesterified
Energy Metabolism
Animals
Adipose Tissue
Lipid Metabolism
Lipid Mobilization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40730294
DOI: 10.1016/j.ajcnut.2025.07.019
PMCID: PMC12674027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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