Article

B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins

2023-02-28

Abstract excerpt

<title>Abstract</title> <p>In a phase I clinical trial, the chimeric hemagglutinin (cHA) immunogen induced antibody responses against the conserved HA stalk domain. However, the landscape of the B cell specificities and subsets induced by this vaccine remain undetermined. Here, we paired single cell RNA-sequencing and B cell receptor repertoire sequencing to analyze the relationship between transcriptome and B ce...

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Literature Corpus work: b642005c-53eb-5095-ac02-ff8021bac385
DOI: 10.21203/rs.3.rs-2600472/v1

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