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Article

Next-generation sequencing of adrenocortical carcinoma reveals new routes to targeted therapies.

Journal of clinical pathology - 1 Nov 2014

Ross J S, Wang K, Rand J V, Gay L, Presta M J, Sheehan C E, Ali S M, Elvin J A, Labrecque E, Hiemstra C, Buell J, Otto G A, Yelensky R, Lipson D, Morosini D, Chmielecki J, Miller V A, Stephens P J

Abstract excerpt

AIMS: Adrenocortical carcinoma (ACC) carries a poor prognosis and current systemic cytotoxic therapies result in only modest improvement in overall survival. In this retrospective study, we performed a comprehensive genomic profiling of 29 consecutive ACC samples to identify potential targets of therapy not currently searched for in routine clinical practice. METHODS: DNA from 29 ACC was sequenced to high,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25078331
DOI: 10.1136/jclinpath-2014-202514
PMCID: PMC4215283

Genes

APC
ATM
CCND2
CDK4
CTNNB1
DAXX
EGFR
ERBB4
KRAS
MDM2
MEN1
MSH2
NRAS
PDGFRB
PTCH1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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