Article

Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development

2017-11-01

Abstract excerpt

<h4>Background</h4> MC1R, a G-protein coupled receptor with high affinity for alpha-melanocyte stimulating hormone (αMSH), modulates pigment production in melanocytes from many species and is associated with human melanoma risk. MC1R mutations affecting human skin and hair color also have pleiotropic effects on the immune response and analgesia. Variants affecting human pigmentation in utero alter the congenita...

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Literature Corpus work: e630246c-295d-53f3-b0b5-cf6fdf77948f
DOI: 10.1101/212712

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