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Article

LINC08148 promotes the caveola-mediated endocytosis of Zika virus through upregulating transcription of Src

14 May 2024

Abstract excerpt

ABSTRACT Long non-coding RNAs (lncRNAs) represent a new group of host factors involved in viral infection. Current study identified an intergenic lncRNA, LINC08148, as a proviral factor of Zika virus (ZIKV) and Dengue virus 2 (DENV2). Knockout (KO) or silencing of LINC08148 decreases the replication of ZIKV and DENV2. LINC08148 mainly acts at the endocytosis step of ZIKV but at a later stage of DENV2. RNA-seq...

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PMID: 38742902
DOI: 10.1128/jvi.01705-23

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