Article

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer

2023-06-28

Abstract excerpt

Ovarian cancer is the deadliest gynecological malignancy of the reproductive organs in the United States. Cyclin-dependent kinase 1 (CDK1) is an important cell cycle regulatory protein that spe-cifically controls the G2/M phase transition of the cell cycle. RO-3306 is a selective, ATP-competitive, and cell-permeable CDK1 inhibitor that shows potent anti-tumor activity in multiple pre-clinical models. In this study...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5684fd4-457a-55cc-babc-3b6185a4fbbb
DOI: 10.20944/preprints202306.2054.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian CancerDOI 10.20944/preprints202306.2054.v1Read

Targeting CDK1 in cancer: mechanisms and implicationsSemantic proximity Read

Inhibitors of Cell Cycle Kinases: Recent Advances and Future Prospects as Cancer TherapeuticsSemantic proximity Read

Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncologySemantic proximity Read

Targeting CDK6 in cancer: State of the art and new insightsSemantic proximity Read

CDK4 and CDK6 kinases: From basic science to cancer therapySemantic proximity Read

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An UpdateSemantic proximity Read

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivoSemantic proximity Read

<i>In vitro</i> antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00Semantic proximity Read

Is Cyclin D1-CDK4 kinase a bona fide cancer target?Semantic proximity Read

Cancer Therapy: Targeting Cell Cycle RegulatorsSemantic proximity Read

Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.Semantic proximity Read

Targeting Cyclins and Cyclin-Dependent Kinases in Cancer: Lessons from Mice, Hopes for Therapeutic Applications in HumansSemantic proximity Read