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<i>In vitro</i> antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00

1 Mar 2007

Abstract excerpt

Cyclin-dependent kinases (Cdk) and their associated pathways represent some of the most attractive targets for the development of anticancer therapeutics. Based on antitumor activity in animal models, a variety of Cdk inhibitors are undergoing clinical evaluation either as a single agent or in combination with other approved drugs. In our anticancer drug discovery program, a novel series of flavones have been...

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PMID: 17363486
DOI: 10.1158/1535-7163.mct-06-0613

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