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Article

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.

Communications biology - 28 Aug 2020

Li Zhonglin, Gaudreault Nathalie, Arsenault Benoit J, Mathieu Patrick, Bossé Yohan, Thériault Sébastien

Abstract excerpt

Calcific aortic valve stenosis (CAVS) is a frequent heart disease with significant morbidity and mortality. Recent genomic studies have identified a locus near the gene PALMD (palmdelphin) strongly associated with CAVS. Here, we show that genetically-determined expression of PALMD in the aortic valve is inversely associated with CAVS, with a stronger effect in women, in a meta-analysis of two large cohorts...

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Identifiers

PMID: 32859967
DOI: 10.1038/s42003-020-01210-x
PMCID: PMC7455695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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