Article

Hemodynamic Disruption Triggers Glomerular Barrier Injury via Endothelial Glycocalyx Degradation in Nephrotic Syndrome

2026-07-03

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> :Nephrotic syndrome (NS) is characterized by severe proteinuria, generalized edema and a hypercoagulable state. The clinical manifestations of NS are well recognized, yet the mechanistic link between renal microhemodynamic disturbance and glomerular filtration barrier (GFB) injury remains poorly defined. Endothelial glycocalyx (EG) serves as a critical vascula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e53fbff3-4568-5b74-aa92-75e626d07f2a
DOI: 10.21203/rs.3.rs-10162867/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hemodynamic Disruption Triggers Glomerular Barrier Injury via Endothelial Glycocalyx Degradation in Nephrotic SyndromeDOI 10.21203/rs.3.rs-10162867/v1Read

A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy.Semantic proximity Read

Laminar flow substantially affects the morphology and functional phenotype of glomerular endothelial cells.Semantic proximity Read

Cellular and molecular mechanisms of diabetic glomerulopathySemantic proximity Read

Cancer Cell Glycocalyx and Its Significance in Cancer ProgressionSemantic proximity Read

Glomerular Endothelial Cells as Instigators of Glomerular Sclerotic DiseasesSemantic proximity Read

Microphysiological uremia model reveals biophysical potentiators of vascular dysfunctionSemantic proximity Read

Endothelial cell dysfunction and glycocalyx - A vicious circle.Semantic proximity Read

Mechanical challenges and cytoskeletal impairments in focal segmental glomerulosclerosisSemantic proximity Read

Pathobiology of focal segmental glomerulosclerosis: new developments.Semantic proximity Read

Functional, proteomic and phenotypic in vitro studies evidence podocyte injury after chronic exposure to heparin.Semantic proximity Read

The endothelial glycocalyx as a potential modifier of the hemolytic uremic syndrome.Semantic proximity Read

The neurovascular extracellular matrix in health and diseaseSemantic proximity Read