Article

Isocitrate Dehydrogenase 1 R132C–Mutant Diffuse Gliomas: Early TP53 Alterations and Implications for Germline Testing in Li- Fraumeni Syndrome

2026-05-21

Abstract excerpt

<title>Abstract</title> <p> Background The non-canonical <italic>isocitrate dehydrogenase 1</italic> ( <italic>IDH1</italic> ) R132C mutation is rare in diffuse gliomas but appears to be enriched in tumors associated with Li-Fraumeni syndrome (LFS), which is caused by germline tumor protein p53 ( <italic>TP53</italic> ) mutations. However, the molecular relationship between <italic>TP53</italic> alterat...

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Literature Corpus work: e5357e29-ec8d-5bf2-8549-6ca13c42b37d
DOI: 10.21203/rs.3.rs-9466402/v1

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