Article

Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures

2025-03-21

Abstract excerpt

<h4>Background: </h4> Von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome, is characterized by mutations in the VHL gene, which result in the stabilization of hypoxia-inducible factors (HIF)-1α and -2α, ultimately leading to the development of highly vascularized tumors, such as hemangioblastomas of central nervous system (CNS-HBs). The standard treatment for these brain tumors is neurosurgic...

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Literature Corpus work: e51c29df-4585-54c8-8b32-024b95647567
DOI: 10.20944/preprints202503.1590.v1

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