Article

Cooperative molecular interaction networks govern PARP1 inhibitor selectivity and binding affinity

2025-10-14

Abstract excerpt

Selective inhibition of PARP1 represents a promising strategy to improve the therapeutic index of PARP inhibitors, a class of anticancer agents that exploit defects in DNA repair pathways. While PARP inhibitors have shown remarkable clinical benefit, particularly in BRCA-mutated tumors, the lack of discrimination between PARP1 and its close homolog PARP2, often leads to hematological toxicity and limits treatment...

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Literature Corpus work: e4f7a4b6-6278-5063-ade7-9caa032b0ef2
DOI: 10.1101/2025.10.13.681983

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