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Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging

19 May 2025

Abstract excerpt

BACKGROUND: The human cornea is a transparent and uniquely ordered optical-biological system. Precise coordination of its cellular mechanisms is essential to maintain its transparency and functionality. However, the spatial, cellular and molecular architecture of the human cornea and its intercellular interactions during aging have not been elucidated. METHODS: We performed single-cell RNA sequencing (scRNA-seq)...

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PMID: 40390022
DOI: 10.1186/s13073-025-01475-z

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