An update on our understanding of host defense mechanisms at the ocular surface; innate immune dysregulation at the ocular surface: lessons from Stevens-Johnson syndrome and related inflammatory disorders.

Abstract excerpt

INTRODUCTION: The ocular surface is a frontline mucosal immune barrier that protects the eye from pathogens while preserving immune tolerance essential for vision. Breakdown of this innate immune homeostasis can trigger chronic ocular surface inflammation, exemplified by Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications (SJS/TEN with SOC) and atopic keratoconjunctivitis (AKC)....

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