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The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy

3 Jun 2025

Abstract excerpt

Mitophagy, the selective degradation of mitochondria, is essential for retinal ganglion cell (RGC) differentiation and retinal homeostasis. However, the specific mitophagy pathways involved and their temporal dynamics during retinal development and maturation remain poorly understood. Using proteomics analysis of isolated mouse retinas across developmental stages and the mitophagy reporter mouse line, mito-QC, we...

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Retinal Development and Disorders
Autophagy in Disease and Therapy
Retinal Diseases and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40472989
DOI: 10.1016/j.jmb.2025.169263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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