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<i>Fmr1</i> mutation reshapes gut microbiome structure, diversity, intestinal barrier integrity, and function in a sex and genotype-dependent manner

2026-03-18

Abstract excerpt

Fragile X Syndrome (FXS) is the leading monogenic cause of autism spectrum disorder (ASD), caused by mutation in the Fmr1 gene. In addition to cognitive and behavioral challenges, FXS patients often experience altered gut microbiome-induced gastrointestinal (GI) problems. Evidence suggests that an altered gut microbiome can disrupt mucosal barrier and promote inflammation, leading to impaired intestinal barrier i...

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Literature Corpus work
e4ab1e3a-40d3-582b-89a8-c72516831e86
DOI
10.64898/2026.03.17.712468
Open publication

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<i>Fmr1</i> mutation reshapes gut microbiome structure, diversity, intestinal barrier integrity, and function in a sex and genotype-dependent mannerDOI 10.64898/2026.03.17.712468
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