Article

Unique features of the gut microbiome characterized in animal models of Angelman Syndrome

2022-07-06

Abstract excerpt

<h4>ABSTRACT</h4> A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux. AS is caused by the loss of ubiquitin ligase E3A ( UBE3A ) gene expression in the brain. Clinical features of AS, which include developmental delays, intellectual disability, microcephaly, and seizures, are primarily due to the deficient e...

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Literature Corpus work: 409d6cdd-6cfb-5ab8-a9ce-df8b3fae3488
DOI: 10.1101/2022.07.05.498914

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