Article

<i>Lactiplantibacillus plantarum</i> PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in <i>Fmr1</i> knockout mice

2025-12-17

Abstract excerpt

<h4>Background</h4> Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathways linking gut ecology to brain function remain incompletely understood. One candidate pathway is polyamine metabolism, which l...

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Literature Corpus work: c66589aa-5f28-5427-9ec3-9e9336e31bb8
DOI: 10.64898/2025.12.15.694366

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