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Article

Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy

5 Sept 2019

Abstract excerpt

Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease-modifying treatment strategies of neuropeptides represent promising candidates. Here, we provide the "proof of concept" that gene therapy by adeno-associated virus (AAV)...

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PMID: 31486590
DOI: 10.15252/emmm.201809963

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