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A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements <i>in vivo</i>

2021-05-18

Abstract excerpt

The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment. These assays have not...

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Literature Corpus work
e4931ce9-cfed-5df2-bf13-5be4822ef713
DOI
10.1101/2021.05.17.444514
Open publication

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