Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the sequential changes of monocytes/macrophages in the progression of IDD with longitudinal approach using single-cell transcriptome

1 Feb 2023

Abstract excerpt

Intervertebral disk degeneration (IDD) is a chronic inflammatory disease with intricate connections between immune infiltration and oxidative stress (OS). Complex cell niches exist in degenerative intervertebral disk (IVD) and interact with each other and regulate the disk homeostasis together. However, few studies have used longitudinal approach to describe the immune response of IDD progression. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Osteoarthritis Treatment and Mechanisms
Share to Spine and Intervertebral Disc Pathology
Share to Spondyloarthritis Studies and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36817437
DOI: 10.3389/fimmu.2023.1090637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the sequential changes of monocytes/macrophages in the progression of IDD with longitudinal approach using single-cell transcriptomePMID 36817437Read ↗

Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc DegenerationSemantic proximity Read ↗

An Oxidative Stress-Related Gene Pair (CCNB1/PKD1), Competitive Endogenous RNAs, and Immune-Infiltration Patterns Potentially Regulate Intervertebral Disc Degeneration DevelopmentSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc DegenerationSemantic proximity Read ↗

Integration of single-cell and transcriptome sequencing data reveals the mechanism of macrophage polarization-related genes in intervertebral disc degenerationSemantic proximity Read ↗

Study on molecular mechanism of intervertebral disc degeneration by single cell hdWGCNA combined with transcriptome sequencingSemantic proximity Read ↗

Comprehensive bioinformatics analyses reveal immune genes responsible for altered immune microenvironment in intervertebral disc degenerationSemantic proximity Read ↗

Significance of oxidative stress in the diagnosis and subtype classification of intervertebral disc degenerationSemantic proximity Read ↗

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc DegenerationSemantic proximity Read ↗

Identification and experimental validation of biomarkers associated with exercise in intervertebral disc degeneration through bulk RNA and single-cell RNA sequencing analysisSemantic proximity Read ↗

The Roles of Blood Lipid-Metabolism Genes in Immune Infiltration Could Promote the Development of IDDSemantic proximity Read ↗

Bioinformatics-Based Discovery of Intervertebral Disc Degeneration Biomarkers and Immune- Inflammatory InfiltratesSemantic proximity Read ↗

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.